Treatment Concepts for the Management of Peri-Implant Disease The management of infectious diseases affecting osseointegrated implants in function has become a demanding issue in implant dentistry. While nonsurgical therapy was effective in the treatment of mucositis lesions, for peri-implantitis, mechanical debridement alone has shown limited efficacy. Adjunctive measures (e.g. local antibiotics/ antiseptics, laser application) may be effective in arresting disease progression at initial sites; however, moderate to advanced peri-implantitis lesions commonly require a surgical intervention. Previous studies have indicated that surgical treatment of peri-implantitis with concomitant placement of a bone filler is associated with clinical and radiographic improvements on both short- and long-term periods. However, the available evidence also suggests, that the effectiveness of regenerative treatment approaches is influenced by several factors, such as the type and configuration of the defect, implant surface characteristics, as well as the method of surface decontamination.